Substrate: GSK-3 beta (Glycogen synthase kinase-3 beta)
Seq-ID: P18266 [Rattus norvegicus]
Download:fasta csv
Interaction Network(s): -
External Source(s): Phosida
MINT Interaction(s):
MINT-46039   CADH1_MOUSE
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein serine/threonine kinase activity,
ionotropic glutamate receptor binding,
tau protein binding,
protein kinase binding,
tau-protein kinase activity,
ATP binding,
integrin binding		 Axin-APC-beta-catenin-GSK3B complex,
dendritic spine,
beta-catenin destruction complex,
cytosol,
soluble fraction,
nucleus,
membrane raft		 protein amino acid phosphorylation,
negative regulation of dendrite morphogenesis,
negative regulation of MAP kinase activity,
regulation of neuronal synaptic plasticity,
establishment of cell polarity,
response to lithium ion,
response to drug,
negative regulation of transcription, DNA-dependent,
Wnt receptor signaling pathway,
induction of apoptosis
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 216 QLVRGEPNVSYICSRYYRAPE - 8382613
LTP
1.00
 - S_TKc
0.08
 1Q5K 79.91%

Substrate: GSK-3 beta (Glycogen synthase kinase-3 beta)
Seq-ID: P49841 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-65985   DBPA_HUMAN
MINT-65986   YBOX1_HUMAN
MINT-2837737   PSN1_HUMAN
MINT-3974216   TAU_HUMAN
MINT-4049759   PCM1_HUMAN
MINT-4049773   NIN_HUMAN
MINT-4508051   CTNB1_HUMAN
MINT-4508259   AXN1_HUMAN
MINT-4793253   P53_HUMAN
MINT-6761890   PTN1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein serine/threonine kinase activity,
tau-protein kinase activity,
p53 binding,
beta-catenin binding,
ATP binding,
protein kinase A catalytic subunit binding,
NF-kappaB binding		 Axin-APC-beta-catenin-GSK3B complex,
beta-catenin destruction complex,
cytosol,
nucleus		 positive regulation of protein catabolic process,
hippocampus development,
negative regulation of apoptosis,
positive regulation of protein export from nucleus,
positive regulation of Rac GTPase activity,
positive regulation of protein complex assembly,
peptidyl-serine phosphorylation,
glycogen metabolic process,
superior temporal gyrus development,
canonical Wnt receptor signaling pathway,
ER overload response,
negative regulation of protein binding,
positive regulation of cell-matrix adhesion
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
T 7     MSGRPRTTSFAESCKPV - 18669648
HTP
0.68
 - -
0.61
 --
S 9   MSGRPRTTSFAESCKPVQQ PKA_group 11035810
LTP
0.60
 MOD_PKA_2
 - -
0.61
 --
S 9   MSGRPRTTSFAESCKPVQQ RSK_group 16039586
LTP
0.60
 MOD_PKA_2
 - -
0.61
 --
S 9   MSGRPRTTSFAESCKPVQQ - 17192257
HTP
0.60
 MOD_PKA_2
 - -
0.61
 --
S 9   MSGRPRTTSFAESCKPVQQ - 18669648
HTP
0.60
 MOD_PKA_2
 - -
0.61
 --
S 21 AESCKPVQQPSAFGSMKVSRD SGK_group 12054501
LTP
0.24
 - -
0.47
 --
T 43 DGSKVTTVVATPGQGPDRPQE MAPK1 16039586
LTP
0.83
 MOD_ProDKin_1
 - -
0.66
 1Q5K 12.33%
T 43 DGSKVTTVVATPGQGPDRPQE MAPK3 16039586
LTP
0.83
 MOD_ProDKin_1
 - -
0.66
 1Q5K 12.33%
Y 216 QLVRGEPNVSYICSRYYRAPE MAP2K1 15020233
LTP
1.00
 - S_TKc
0.08
 1Q5K 79.91%
Y 216 QLVRGEPNVSYICSRYYRAPE - 17081983
HTP
1.00
 - S_TKc
0.08
 1Q5K 79.91%
Y 216 QLVRGEPNVSYICSRYYRAPE - 17192257
HTP
1.00
 - S_TKc
0.08
 1Q5K 79.91%
Y 216 QLVRGEPNVSYICSRYYRAPE - 16964243
HTP
1.00
 - S_TKc
0.08
 1Q5K 79.91%
Y 216 QLVRGEPNVSYICSRYYRAPE - 18083107
HTP
1.00
 - S_TKc
0.08
 1Q5K 79.91%
Y 216 QLVRGEPNVSYICSRYYRAPE - 18669648
HTP
1.00
 - S_TKc
0.08
 1Q5K 79.91%
T 390 PHARIQAAASTPTNATAASDA - 17192257
HTP
0.15
 - -
0.72
 --
T 390 PHARIQAAASTPTNATAASDA - 18669648
HTP
0.15
 - -
0.72
 --
T 392 ARIQAAASTPTNATAASDANT - 18669648
HTP
0.31
 - -
0.76
 --
T 402 TNATAASDANTGDRGQTNNAA - 15302935
HTP
0.16
 - -
0.85
 --

Substrate: GSK-3 beta (Glycogen synthase kinase-3 beta)
Seq-ID: Q9WV60 [Mus musculus]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein serine/threonine kinase activity,
tau-protein kinase activity,
beta-catenin binding,
ATP binding		 neuronal cell body,
Axin-APC-beta-catenin-GSK3B complex,
cytosol,
dendritic shaft,
nucleoplasm,
soluble fraction,
growth cone		 fat cell differentiation,
myoblast fusion,
organ morphogenesis,
anti-apoptosis,
positive regulation of peptidyl-serine phosphorylation,
cell migration,
protein export from nucleus,
positive regulation of apoptosis,
peptidyl-serine phosphorylation,
canonical Wnt receptor signaling pathway,
ER overload response,
positive regulation of peptidyl-threonine phosphorylation,
re-entry into mitotic cell cycle,
cell proliferation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
T 7     MSGRPRTTSFAESCKPV - 17242355
HTP
0.74
 - -
0.61
 --
S 9   MSGRPRTTSFAESCKPVQQ PKA_alpha 11035810
LTP
0.70
 MOD_PKA_2
 - -
0.61
 --
S 9   MSGRPRTTSFAESCKPVQQ - 15845746
LTP
0.70
 MOD_PKA_2
 - -
0.61
 --
S 9   MSGRPRTTSFAESCKPVQQ - 16522636
LTP
0.70
 MOD_PKA_2
 - -
0.61
 --
S 9   MSGRPRTTSFAESCKPVQQ - 17141160
LTP
0.70
 MOD_PKA_2
 - -
0.61
 --
S 9   MSGRPRTTSFAESCKPVQQ - 17052453
LTP
0.70
 MOD_PKA_2
 - -
0.61
 --
S 21 AESCKPVQQPSAFGSMKVSRD - 15710331
LTP
0.16
 - -
0.47
 --
S 215 KQLVRGEPNVSYICSRYYRAP - 17114649
HTP
0.93
 - S_TKc
0.09
 1Q5K 22.95%
Y 216 QLVRGEPNVSYICSRYYRAPE - 15592455
HTP
1.00
 - S_TKc
0.08
 1Q5K 79.91%
Y 216 QLVRGEPNVSYICSRYYRAPE - 17242355
HTP
1.00
 - S_TKc
0.08
 1Q5K 79.91%
Y 216 QLVRGEPNVSYICSRYYRAPE - 17114649
HTP
1.00
 - S_TKc
0.08
 1Q5K 79.91%
S 219 RGEPNVSYICSRYYRAPELIF - 17242355
HTP
1.00
 - S_TKc
0.06
 1Q5K 22.95%
S 389 PPHARIQAAASPPANATAASD - 15345747
HTP
0.31
 - -
0.70
 --
S 389 PPHARIQAAASPPANATAASD - 17114649
HTP
0.31
 - -
0.70
 --
T 395 QAAASPPANATAASDTNAGDR - 17114649
HTP
0.05
 - -
0.81
 --

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